Answer Questions Assignment Example | Topics and Well Written Essays - 1000 words

Answer Questions - Assignment Example Another interesting development involves dealing with tactical purchasing activities that leverage information for organizations. Consequently, the interaction and collaboration of the aforementioned functions play a fundamental role in departments such as Marketing, Legal, Engineering and Quality and Manufacturing among others. This is through the implementation of varying functions that tackle retail business during transactions. Additionally, there are processes that are valuable to measurement systems that used in supply management agencies to facilitate functional organizational structures. There are lots of differences between the principles and practices of Purchasing and Supply Management used in the Public sector and the Private Sector. For example, while in the former that majorly comprises of the government the rules are based on contract negation, the latter concentrates on procurement subcontract. Alternatively, while in government they focus on the legal aspects that characterize purchasing, in manufacturing and retail the fundamental features include acquisition and logistics management. Likewise, the salient points noted in the discussion include the need for value-added flow of resources that are later disbursed to resellers and final consumers. In the same capacity, a customer-focused approach is integral in improving efficiency to leverage on the elements of supply chain (Monczka et al 145). Therefore, the salient differences affect the establishment that influences buyer-supplier relationships through the aspects of distribution management, channel manag ement, and payment management. On the other hand, issues of outsourcing and product development assume a huge precedent in maintaining the customer service flow. Likewise, in terms of implementation of the Purchasing and Supply Management function, concentration on external collaboration and

Inborn errors of metabolism

Inborn errors of metabolism 1.0 Abstract Inborn errors of metabolism occurs 1 in 5000 births collectively. They can be treated if the inborn error is diagnosed properly and early. They are manly caused by a gene defect that blocks vital metabolic pathways. The can be server, which is mainly due to amount of enzymes that is causing the block or deficiency of the reaction product. This can affect the organs and also have local effect such as lysosomal storage disease. The symptoms can vary, from mild to severe. They affect any organs and occur at any time. To recognise the Inborn Errors of Metabolism, the doctor must be suspicious; for example a baby that show signs of antecedent maternal fever should undergo a blood culture and also undergo simple tests such as Amino acids, Organic acids, Glucose, Electrolytes, Lactate, and Ammonia; which is done in the laboratory. 2.0 Abstract Inborn errors of metabolism (IEM) are a group of genetic disorders that are rare. These disorders are genetic diseases that are involved in metabolism disorders. A large section of these disorders arise from single genes that encodes for enzymes; that have been defective. These enzymes are important that they catalyses chemical reactions converting substrates to products essential for everyday living. Inborn errors of metabolism disorders can arise from a number of conditions such as prolong exposure and accumulation of substances which are toxic, and the interference of normal functions and the inability to produce and synthesize essential compounds. Inborn errors of metabolism has related to defects in or damage to a developing foetus that may have been caused to genetic changes, that is why Inborn errors of metabolism is sometimes referred as congenital metabolic diseases. Inborn errors of metabolism have also been linked to heritable disorders within biochemistry, for example phe nylketonuria (PKU). That is why some times it is referred as inherited metabolic diseases as well. In the perspective of changes of normal mechanical, physical, and biochemical functions, IEM can divided into three useful groups that can be analysed diagnostically. Group 1: Disorders which causes intoxication. Group 2: Disorders involving energy metabolism. And Group 3: Disorders involving complex molecules. 1.0 Introduction 1.1 Inborn Errors of Metabolism In the early 1900s, a researcher called Sir Archibald Garrods based his studies on genetic metabolic disorders and discovered IEM [1, 2]. He was known for his work on the one gene, one enzyme hypothesis, based on his studies on the nature and inheritance of alkaptonuria. And gave the name and wrote a book on IEM (The Incidence of Alkaptonuria: a Study in Chemical Individuality.) [1, 2]. IEM can arise from a number of causes, but the major cause is alteration of a specific metabolic reaction [1, 2]. IEM has been shown to develop at a very young age, where epidemiology findings indicated that hundreds of IEM affects about 1 in every 5000 born babies [2]. But as technology advances and improved techniques such as metabolomics, has been easy to develop newborn screening that improves early diagnosis and treatment in a number of IEM disorders [2]. But as these new techniques cost a lot to run and time increases, proving to be unreliable [2]. The study and the knowledge about inborn errors of metabolism (IEM) have improved due to the latest advancement in technology and techniques [2, 3]. These improvement have led us to the conclusion, for example urea cycle disorders and organic acidemias may and will lead to the accumulation of ammonia, which is a toxic product of amino acid metabolism [2, 3]. Also the latest findings are that inborn errors of metabolism (IEM) may impair brain function due to defects in the mitochondrial respiratory chain and disorders in gluconeogenesis [4]. There are 10 facts that need to take inconsideration when people with IEM undergo clinical diagnosis [5]. Common condition such as, intoxication, encephalitis and brain tumours in older patients and also sepsis have to be analysed properly and always consider IEM in the same field [5]. Symptom that persists and that are unexplained even before, during and after initial treatment and usual investigations has been performed, have to be taken to consideration that it could be IEM [5]. Newborn babies that have organ dysfunction, hypo-perfusion, or hypotension can develop sepsis, which can be caused by IEM. So any babies in neonatal intensive care unit that die, the first cause that has to be taken to account is IEM [5]. Have to take extra care in reviewing all autopsy findings [5]. The examiner must not confuse a symptom for example peripheral neuropathy; or syndrome such as sudden infant death with etiology [5]. IEM can develop and present at any age, for example from foetal life to old age [5]. The examiner must take to account that not all genetic metabolic errors causes are due to hereditary and transmitted recessive disorders, but a large section of individual cases are sporadic [5]. Always consider inborn errors of metabolism are open to treatment for example with patients that have inborn errors of metabolism due to intoxication [5]. In server situations, the examiner will need to take a few patients with IEM that are able to diagnose and treat the patient with IEM [5]. The examiner must be open to obtain help from specialised centres that specialise with IEM [5]. The metabolic disorders can be set into three useful groups that can easily be distinguished from each other [5, 6, 7]. These three groups are sorted from a pathophysiological point of view [5, 6, 7]. The groups are; Group 1: Disorders which is caused by intoxication [5, 6, 7]. Group 2: Disorders involving energy metabolism [5, 6, 7]. And Group 3: Disorders involving complex molecules [5, 6, 7]. 1.2 Group 1- Disorders which is caused by intoxication In this group, it describes inborn errors of intermediary metabolism. These inborn errors cause acute of progressive intoxication from long exposure and increase of toxic compounds, forming a metabolic block [5, 6, 7]. In group 1 the inborn errors are manly amino acid catabolism [5, 6, 7]. These include phenylketonuria, where there is a deficiency in the enzyme phenylalanine hydroxylase (PAH); which is needed to metabolise the amino acid phenylalanine to the amino acid tyrosine [5, 6, 7]. Homocystinuria is an inherited disorder of the metabolism of methionine [5, 6, 7]. Tyrosinemia is where body cannot break down the amino acid tyrosine [5, 6, 7]. Also organic acidurias such as methylmalonic acidemia, and propionic acidemia [5, 6, 7]. Sugar intolerances are also classified in group 1 [5, 6, 7]. These include hereditary fructose intolerance caused by a deficiency of liver enzymes that metabolise fructose. Metal toxication also falls under group 1; such as hemochromatosis, where the patient has accumulated a lot of iron [5, 6, 7]. All these metabolic disorders have something in common, in that they do not affect the embryo development, and also show similar symptoms of clinical intoxication [5, 6, 7]. A patient with group 1 disorders may show an acute signs of vomiting, coma and liver failure; or chronic signs which are cardiomyopathy, developmental delay and failure to thrive. Acute symptoms that can worsen are catabolism, fever, and food intake [5, 6, 7]. The analysis in group 1 is easy, and without any complications [5, 6, 7]. It needs the use of chromatography in which the plasma and urine amino acid. Most of group 1 disorders are treatable. Treatment is usually involves special diets and cleansing drugs such as sodium benzoate and penicillamine, to remove the toxins [5, 6, 7]. The inborn error of amino acid synthesis is also included to this group, as they have the same or similar features [7, 8]. They are inborn errors of intermediary metabolism; the analysis requires the plasma and urine where disorders are able to be treated even when the disorder starts with in the uterus, for example 3-phosphoglycerate dehydrogenase deficiency [5, 6, 7, 8]. 1.3 Group 2- Disorders involving energy metabolism In this group inborn errors are errors of intermediary metabolism as well. The symptoms are mainly caused by a lack of energy production or utilization. This will involve the liver, myocardium, muscle, and brain [5, 6, 7]. There are two types of disorders involving energy metabolism. 1. involves mitochondrial energy defects. 2. involves cytoplasmic energy defects [5, 6, 7]. Mitochondrial energy defects are more aggressive and are not fully treatable [5, 6, 7]. Mitochondrial energy defects cause lactic acidemias where there is dextrorotatory lactic acid in the circulating blood, resulting to defects of the pyruvate transporter resulting to PKU, pyruvate carboxylase this causes lactic acid to accumulate in the blood, pyruvate dehydrogenase where the patient can show symptoms of severe lethargy, and defects in the Krebs cycle [5, 6, 7]. But some defects such as fatty acid oxidation and ketone body defects are partly treatable [5, 6, 7]. Cytoplasmic energy defects are not as much aggressive then mitochondrial energy defects. A cytoplasmic energy defect causes disorders of glycolysis, glycogen metabolism and gluconeogenesis [5, 6, 7]. And recent study showed it causes disorders of creatine metabolism which it is partly treatable by oral creatine supplementation [5, 6, 7]. Cytoplasmic energy defects can cause disorders that are untreatable, such as errors of the pentose phosphate pathway which will be described in further details [5, 6, 7]. In group 2, the common symptoms are heart muscle disease, hypoglycaemia, myopathy which is a muscular disease, cardiac failure, specific failure of the circulation, sudden death especially in infancy [5, 6, 7]. Mitochondrial disorders and as well as the pentose phosphate pathway defects can obstruct embryo-foetal development and give rise to dysmorphism, dysplasia causing an abnormality in maturation of cells within a tissue and congenital disorder [5, 6, 7, 9]. The analysis and the diagnosis are hard to put through as it requires 4 different tests [5, 6, 7]. 1. Function tests [5, 6, 7]. 2. Enzymatic analyses needing biopsies [5, 6, 7]. 3. Cell culture [5, 6, 7]. 4. Molecular analyses [5, 6, 7]. 1.4 Group 3- Disorders involving complex molecules. Group 3 involves cellular organelles [5, 6, 7]. The diseases that fall under group 3 modify the synthesis or the catabolism of complex molecules [5, 6, 7]. There are symptoms that are permanent and progressive, and some symptoms free from intercurrent events [5, 6, 7]. In this group there are disorders such as lysosomal storage disorders, peroxisomal disorders and inborn errors of cholesterol synthesis etc. In this group treatment is difficult would need enzyme replacement therapy, especially for lysosomal disorders [5, 6, 7, 10]. 2.0 General Symptoms and Signs There is a way for testing newborn babies for inborn errors [11]. This process is called Newborn screening. This tests babies at a very early age for four types of diseases that are treatable: genetic, endocrinologic, metabolic and hematologic diseases [11]. Dr Robert Guthrie was a microbiologist who designed a dried blood spot testing, and used it to screen for phenylketonuria [12]. To this present day that spotting test is still being used. As techniques have improved so have the screening [12]. A physician who is screening a newborn baby for a metabolic disorder has follow four groups of clinical circumstances: The physician must find early symptoms, especially in the antenatal and neonatal period of development. In the later stages the physician must find symptoms that are server and recurring. Symptoms such as coma and vomiting. If the physician finds any symptoms that are chronic and aggressive, they could be due to three things: 1) Gastrointestinal. 2) Muscular. 3) Neurological. These will be described in more detail below The physician must find any signs of cardiomyopathy, hepatomegaly etc. This could lead to organ failures. The three groups have symptoms that are chronic and aggressive that can be easily ignored or misinterpreted. 2.1 Gastrointestinal Symptoms. If a patient has inborn errors of metabolism (IEM), the person might have symptoms that fall under the Gastrointestinal Symptoms (GI) group [13]. These symptoms include Anorexia, which is an eating disorder [5, 13]. Osteoporosis which untreated could lead to bones fracturing. Chronic vomiting, feeding difficulties, and failure to thrive are also symptoms of (GI). But they are also associated with chronic diarrhoea [5, 13]. This could lead to false and the wrong diagnosis [5, 13]. There are two groups that have been described to have caused chronic diarrhoea and failure to thrive within inborn errors of metabolism: These disorders include errors of the intestinal mucosa or the exocrine function of the pancreas, for example congenital chloride diarrhoea, glucose- galactose malabsorption a condition in which the cells lining the intestine cannot take in the sugars. Lactase and sucrose-isomaltase deficiencies where the person is unable to metabolise lactose or sucrose. Abetalipoproteinemia type II disorder that interferes with the normal absorption of fat and fat-soluble vitamins from food [5, 13]. Enterokinase deficiency; Enterokinase is an enzyme involved in human digestion. Acrodermatitis enteropathica, a condition that affects that absorption of Zinc. Etc [5, 13]. Systemic disorders such as diabetes mellitus, diabetes, sickle cell disease, sarcoidosis, etc can also give rise to GI abnormalities. A problem has risen in distinguishing systemic abnormalities and inborn error of metabolism and vice versa [5, 13]. 2.2 Muscle Symptoms. There are a number of symptoms that fall under this group. For example: Hypotonia, where there is a disorder that causes low muscle tone and strength [5, 14]. Muscular weakness and poor muscle mass [5, 14]. These symptoms are common with many inborn errors of metabolism. These symptoms can be caused by urea cycle defects and many amino acid metabolism disorders [5, 14]. Recent studies have shown that the cause of muscle symptoms can be due to mutations in the monocarboxylate transporter 8 gene, which can develop Allan-Herndon-Dudley syndrome [14]. Allan-Herndon-Dudley syndrome falls under the muscle symptoms group as it causes hypotonia, general weakness of the muscle, reduced muscle mass and delayed development [14]. Further studies showed that this X-linked mental retardation syndrome is involved in the transport of triiodothyronine into neurones and disrupts the blood levels of thyroid hormone [14]. 2.3 Neurological Symptoms. Patients with inborn errors often have neurological symptoms. These include of neurological abnormalities, in the central and peripheral system. Studies have shown that these neurological symptoms are very frequent with inborn errors [5, 15]. These symptoms include poor feeding, hypotonia, ataxia, and even autistic features [5, 15]. The analysis of inborn errors, due to the screening of neurological symptoms is very difficult due to symptoms that are non specific signs; sings that include for example developmental delay, and hypotonia [15]. 3.0 Screening Newborns for Inborn Error of Metabolism 3.1 Newborn screening Newborn screening is a technique, used to detect inborn errors [17, 12]. It was first used to detect phenylketonuria (PKU) by a bacterial inhibition assay, developed in the 1961 by Dr Robert Guthrie as already stated. His technique in using dried blood sample was further developed in the mid 1975, where a scientist called Dussault used a method to screening for congenital hypothyroidism [16]. A lot of time and money has been invested into the screening programme, and now they have uncovered new disorders that are related to inborn errors [17, 12]. Disorders such as cystic fibrosis, congenital adrenal hyperplasia, which is a form mutation of genes that produces enzymes that mediating production of cortisol from cholesterol by the adrenal glands. Glucose-6-phosphate dehydrogenase deficiency and many more [5]. To this present day, for screening newborns, tandem mass spectrometry is used [18]. It is a lot easier for screening and diagnosis. The application of tandem mass spectrometry to newborn screening was first described in 1990 [18]. The primary aim of newborn screening is to identify patients, manly infants with serious disorders that are treatable [18]. This will make it easy to prevent or improve clinical symptoms of the disease [18]. Tandem mass-spectrometry is very useful in detecting more than one disorder at one time [18]. This can be used to detect early untreatable disorders and also can be beneficial if the screening was not limited to just individual babies, but the whole family as well [18]. The screening process uses MSMS [18]. MSMS is the method used to measure analytes by both mass and structure [18]. First the compounds are ionised, where the first mass spectrometer selects the ion of interest, where it is sorted by weight [18]. Then the compounds travel through a collision cell, are dissociated to signature fragments, and then pass into a second mass spectrometer where ions are selected for detection. [18]. 3.2 Method for screening Research have been done where most newborn screening programmes use simplifying sample preparation, instead derivatisation of the sample which is the old method [18]. When investigating, the sample might show more than one disorder. But the use of ratio of analytes improves sensitivity and specificity [19]. Specialised biochemical genetic testing is always done to verify which type of disorder the patient has [18]. Theses genetic tests include amino acid analysis, organic acid analysis by gas chromatography/mass spectrometry, and plasma acylcarnitine profile by MSMS [18]. 4.0 Screening for Individual Inborn Errors of Metabolism Well over 40 inborn errors of metabolism can now be detected by newborn screening [20]. This section will look at three inborn errors. 4.1 Pentose Phosphate Pathway The pentose phosphate pathway (PPP) is an anabolic pathway where is uses a 6 carbon glucose to generate a 5 carbon sugars and reducing equivalents, as shown in Fig. 1. There are three primary functions of this pathway [21]: To generate reducing equivalents, such as NADP forming NADPH. NADPH allows reduction biosynthesis reactions to occur within cells [21]. To produce ribose-5-phosphate (R5P) for the cell, for the synthesis of the nucleotides and nucleic acids [21]. Can metabolise dietary pentose sugars that are derived from digestion of nucleic acids [21]. These also rearrange the carbon skeletons of dietary carbohydrates into glycolytic/gluconeogenic intermediates [21]. 4.1.1 Disorders of the Pentose Phosphate Pathway There are three inborn error in the pentose phosphate pathway that have been identified [21]. 4.1.2 Glucose-6-phosphate dehydrogenase deficiency The enzyme glucose-6-phosphate dehydrogenase (G6PDH), catalyses the reaction that converts glucose-6-phosphate to 6-phosphogluconate. This creates one mole of NADPH each for every mole of glucose-6-phosphate (G6P) that enters the PPP [21]. A deficiency would lead to an error to the first irreversible step of the pathway [21]. This would lead further to a lower production in NADPH, making the cell more acceptable to oxidative stress [21]. G6PDH is very important for Erythrocytes metabolism [21]. A deficiency could lead Individuals to nonimmune hemolytic anaemia which can be caused by, infection or exposure to certain medications or chemicals [21]. G6PDH deficiency is also linked to favism [21]. It is thought to be an X-linked recessive hereditary disease [21]. 4.1.3 Ribose-5-Phosphate Isomerase Deficiency A recent study have shown that a patient with of ribose-5-phosphate isomerise deficiency, had developed progressive leucoencephalopathy and, developmental and speech delay [21]. They did further studies using NMR and found that polyols ribitol and D-arabitol concentration was abnormal in body fluids [21, 22]. They did their studies on fibroblasts and found that the enzyme gene-sequence analysis showed a frame-shift and a missense mutation [22]. 4.1.31 Metabolic Derangement Ribose-5-phosphate isomerase deficiency would mean that the reversible reaction converting ribose-5-phosphate to ribulose-5-phosphate and vice versa will halt [22]. If there was no deficiency ribulose-5-phosphate would be converted to xylulose 5-phosphate, which will provide the substrates for transketolase and further conversion into glycolytic intermediates [22]. Studies have found that there are two mutant allele one from each parents that results in ribose-5-phosphate isomerise gene that causes the deficiency [22]. So it could be an autosomal recessive inheritance disorder [22]. The best way to do a diagnostic test for Ribose-5-phosphate isomerase deficiency would be to take a urine sample [22]. Polyols ribitol and D-arabitol would be analysed [22]. Also enzyme assay can be used to sequence the ribose-5-phosphate isomerise gene [22]. 4.1.4 Transaldolase Deficiency Some studies have been done where three unrelated families had Transaldolase deficiency [23]. One patient had aortic coarctation where the aorta narrows [23]. During the patients life they found that ammonia was rising. But neurological and intellectual development has been normal. Another patient had HELLP syndrome (hemolysis, elevated liver enzymes and low platelet count) [23, 24]. Children with transaldolase deficiency have been diagnosed have found that the development of intellectual and neurological showed no abnormalities [23, 24]. But there is a strong link to liver cirrhosis which results from increased cell death of hepatocytes and biliary epithelial cells [23, 24]. 4.1.41 Metabolic Derangement Transaldolase catalyses the reaction: Sedoheptulose 7-phosphate + glyceraldehyde 3-phosphate erythrose 4-phosphate + fructose 6-phosphate [59]. It is a reversible reaction in the pentose phosphate pathway. The deficiency lead to the accumulation of polyols derived from the pathway intermediates: erythritol, arabitol and ribitol [59]. Studies have shown that all patients were homozygous for these specific mutations, suggesting autosomal recessive inheritance [23, 24]. A simple urine test can be done to diagnose of transaldolase deficiency, mainly because there is a high concentration of arabitol and ribitol in urine. Also enzyme assay can be used to sequence the gene [23, 24]. Liver transplant would be the only option with patients that have severe liver cirrhosis [23, 24]. 4.2.0 Insulin secretion by the pancreatic ß-cell In the production of insulin glucose enters the ß-cell through a GLUT2 transporter where it is phosphorylated to glucose-6-phosphate by the enzyme glucokinase [58]. The enzyme is used as a control, where it monitors the level of glucose [58]. As blood glucose raises the rate of glucose metabolism also increases, where the cell will undergo glycolysis generating ATP [58]. This increase of ATP concentration causes K+ channels to close, making the membrane depolarised [58]. This depolarisation causes the voltage sensitive Ca2+ channels to open and Ca ions flood in, stimulating insulin secretion by exocytosis from storage granules; this is shown in Fig. 2. 4.2.1Persistent Hyperinsulinemic Hypoglycaemia Hyperinsulinism has been diagnoses in all ages but it is very common in childhood [25]. Persistent hyperinsulinemic hypoglycaemia (PHHI) is the one of the main cause of hypoglycaemia especially in young children. Patients who are older, that develop PHHI are due to pancreatic adenoma [25]. Hypoglycaemia when there is an overproduction of insulin by the ß-cells in the pancreas [25]. Hypoglycaemia can produce a variety of symptoms the most dangerous is brain damage which can lead to death, and that is why treatment is vital [25]. PHHI has two histopathological lesions that can be easily distinguished, making PHHI a heterogeneous disorder [25]. Focal hyperinsulinemic hypoglycaemia (FoPHHI) is caused by loss of heterozygosity which is a somatic event [25]. This causes focal adenomatous hyperplasia, which is a pancreatic lesion [25]. They are treated with pancreatectomy, where they surgically remove part of the pancreas. Diffuse hyperinsulinemic hypoglycaemia (DiPHHI) is also a heterogeneous disorder, in that fact that it is unable to encode for proteins needed for insulin secretion [25]. This can also be caused autosomal recessive and dominant genes which are rare [25]. Positron emission tomography (PET) is used to distinguish between focal and diffuse PHHI [25]. This gives a 3D image or picture of functional processes in the body [25]. Once a patient is diagnosed with PHHI, they are on treatment straight away with glucose and glucagon [25]. 4.2.12Metabolic Derangement Hyperinsulinemic hypoglycaemia is due to insulin hypersecretion by the pancreas [25]. The Action insulin causes a decrease in plasma glucose by inhibiting hepatic glucose release from glycogen and gluconeogenesis, and by increasing glucose uptake in muscle and fat [25]. PHHI is a disorder that is caused by a variety of defects, either in regulation of insulin secretion, unable to transcribe the enzymes needed of even a modified receptor [26]. For example diseases that can affect the ion channels like seizures [27, 28, 29]. Also lack of enzyme production of glucokinase (GK), and glutamate dehydrogenase (GDH) [30, 31]. Epidemiology has found that 1/50,000 patients are born with PHHI [32, 33]. Focal hyperinsulinemic hypoglycaemia is strongly linked to mutation of the sulfonylurea-receptor and the K+ channels, both used to depolarise the cell [32, 33]. Both are found to be located on the chromosome 11p15 [32, 33]. To identify these mutations they would need to be tested in a foetus or embryo before it is born. Sulfonylurea-receptor gene (SUR1) will not respond to diazoxide, which is used as a K+ channels activator [34]. Studies have found that a high activity of the enzyme glutamate dehydrogenase (GDH) has resulted to hyperinsulism/hyperammonemia syndrome. This would make sense as GDH is needed to produce insulin and this would impair detoxification of ammonia in the liver [31]. The enzyme glucokinase (GK) is also expressed highly, where the affinity is increased for glucose, causing high levels of insulin secretion [30]. 4.2.13 Diagnostic Tests Diagnostic of HI is easy, in the fact that, it can be indicated by the levels of glucose in the blood. Treatment varies from age [35]. Hyperammonemia should be treated as another disease, when a patient has PHHI, when treating hyperinsulism/hyperammonemia syndrome. This can be done by analysis of urine organic acids and plasma acylcarnitines [36]. Patients who show the FoPHHI can have lesion ranging from 2.5 to 7.5 mm in diameter [37, 38]. People who have DiPHHI found that there was ß-cells that were abnormal [39]. Pancreatic venous catheterization (PVS) and pancreatic arteriography have proven very useful in locating the site of insulin secretion [40, 41]. PVS procedure will have to able to maintain blood glucose level, which is between 2 and 3 mmol/l. Blood sample would then be taken from the pancreas to measure 3 things 1.plasma glucose, 2.insulin and 3.C-peptide levels [40, 41]. Studies have shown that people with FoPHHI tend to have high concentration of plasma insulin and C-peptide levels in some samples and low concentration in others [40, 41]. People who have DiPHHI tend to find that all their sample have high concentration of plasma insulin and C-peptide [40, 41]. The use of [18F]-labelled fluoro-L-DOPA whole-body positron emission tomography (PET), has proved to be very useful in detecting hyperfunctional islet pancreatic tissue, where this can be used on patients with focal lesion [42]. Recent studies have shown that a new technique have been use to locate focal lesion and separate focal from diffuse forms of HI; this is the tolbutamide test [44, 45]. 4.2.14 Treatment and Prognosis Brain damage can occur if you are hypoglycaemic, so treatment needs to be quick. Glucagon would be given, where the patient would have to take 1 to 2 mg per day if blood glucose levels are unstable [35]. To treat PHHI, diazoxide would be given, usually at a dose of 15-10 mg/kg/day depending on your age [35]. Normal blood glucose levels should be between 4 and 7 mmol/l, before and after a meal [56]. This could need to be check every time once taking diazoxide [35, 56]. Octreotide treatment, can also be used as it is a hormone inhibitor [46]. But a high could lead to a more severe hypoglycaemia, as it can inhibit glucagon and growth hormone [46]. Patients will find that after treatment with octreotide, they might vomit or have diarrhoea [46]. Calcium-channel blockers could be used, such as Lercanidipine and Pranidipine [46]. These treatments that have been mentioned are very effective in controlling blood sugar [46]. If a patient is diagnosed with FoPHHI, the treatment tends to be surgical as drugs are ineffective [46]. They would undergo pancreatectomy. This procedure has its risk as the patient might develop diabetes mellitus [46]. DiPHHI patients have been found to have large nuclei in the ß-cells [35, 47]. And patients with FoPHHI showed no abnormal s-cell nuclei but did show shrunken cytoplasm [49, 50]. 4.3 Glucose Transporter Deficiency Monosaccharides such as glucose and fructose have the properties of being hydrophilic [59]. The lipid bilayer has hydrophilic heads and hydrophobic tails, prevent polar molecule such as glucose from diffusing across the membrane [59, 60]. So transport mechanisms are needed. These are hydrophilic pores allowing polar molecules to diffuse in and out of the cell [59, 60]. There are two types of glucose transporters. 1. Sodium-dependent glucose transporters (SGLT), which have been found to be located in the small intestine and the proximal tubule [59, 60]. SGLT uses the difference in concentration of sodium to transport glucose [59, 60]. From high to low concentration of sodium causes the transport of glucose against its own concentration gradient [59, 60]. 2. Facilitative glucose transporters (GLUT), which has been found throughout the body, but manly in muscle and pancreas cells [59, 60]. These transporters transport glucose from high to low concentration [59, 60]. Studies have shown that there are four defects in the transport of monosaccharides [59, 60]. These defects can depend on where the transporters are located within the body and what they transport in and out of the cell [59, 60]. As already stated there are four defects. 1. SGLT2, which is found in renal tubulus cells that can cause renal glucosuria [59, 60]. 2. SGLT1, which is found in the intestine, which can cause glucose-galactose malabsorption [59, 60]. 3. GLUT2, a transporter that carries glucose to the liver kidneys and pancreas [59, 60]. 4. GLUT1 is important, in the fact that it carries glucose to the brain cell (neuron and glia cells)

Potemkin :: essays research papers

Setting: While originally filmed to commemorate the 1905 revolution in Russia, Potemkin was actually shown to rouse the masses against the Russian government. The film takes place on three major settings. The battleship Potmekin serves as the first backdrop where the revolution begins. The setting shifts to the Odessa Steps when the sailors arrive with Vakulinchuk ‘s body. Here the Russian soldiers attempt to squelch the uprising by shooting and trampling the crowds which had gathered on the steps. The final scenes take place on the water. The Potemkin sails out to confront the Russian ships, but the sailors eventually realize that the other soldiers had joined them in their revolt. Atmosphere: The atmosphere of the film is dramatic and therefore easily holds the attention of the viewer. Einstein effectively uses the element of suspense to involve the audience. At the start of the film, the sailors were not very willing to cause any commotion or problems. However, once they were confronted with the possibility of being hanged and became fed up with eating rotten meat, they rallied around Vakulinchuk. The mood of the film changed several times. While the main theme was rebellion against the Soviets, there were other emotions portrayed also. When Vakulinchuk’s body was brought ashore for viewing, there was overwhelming anger and sadness felt by many in the crowds. After the people decided to revolt, they mood became much lighter as they took food, coal, and water to the sailors. This joyous time was immediately brought to a halt when the Russian soldiers began marching down the Odessa Steps. Eisenstein again used suspense in these scenes by quickly flashing pictures of the mother with her baby carriage and the approaching soviet â€Å"machine†. Conflict: The film’s major conflict is between the revolting sailors and the Russian officers of the Potemkin. The Russian citizens also become involved in the conflict once Vakulinchuk’s body is viewed. The conflict continues until the Potemkin sails out to meet the Russian fleet. The climax occurs when the two ships face each other in a suspenseful moment.

Impacts of Tourism on National Parks (UK) Essay

National parks around the world are increasingly attracting visitors to experience pristine and unique natural environments. National Parks are extensive tracts of the countryside that have been given strong protection under legislation for the conservation and enhancement of their special qualities. According to the Environments Act (1995) National Parks were designated for two statutory purposes: 1- To conserve and enhance the natural beauty, wildlife and cultural heritage and 2- To provide opportunities for the understanding and enjoyment of the Park by the public. The National Park Authorities (NPA) are responsible for the overall management of National Parks their duty is to ensure that the two objectives of National Parks are fulfilled. TOURISM IMPACTS Tourism impacts are the effects that tourists and tourists activities have on a destination. We will be looking at three main types of impacts that tourism can have on a destination. They are environmental, socio-cultural as well as economic impacts. The word impact gives a negative meaning however tourism impacts can be both positive and negative on a destination. Environmental Impacts (physical – what can be seen) – It is not possible to develop tourism without incurring environmental impacts. Tourism development and activities (litter / pollution) can gradually destroy an environment’s resources. Many of these impacts involves the construction of infrastructure e.g. Creation of roads; hotels & airports etc. Tourism has the potential to create beneficial effects on the environment by contributing to environmental protection and conservation. Tourism can also raise awareness of environmental values and it can serve as a tool to finance protection of natural areas and increase their economic importance. Economic Impacts – There is no doubt that tourism has a large effect on the  economy of a destination. Tourism contribute to sales, profits, employment opportunities for locals (transportations, accommodations), and generate income for payment of goods and services provided. Socio-Cultural Impacts – The outcome of social relationships that occur between tourists and hosts when in contact. Socio-cultural impacts can have an effect on a destination’s culture to the behaviour of its residents. It is considered to be the changes in the quality of life of residents of tourist destinations. Destinations involved in the tourism business experience socio-cultural changes as a result of tourism activity, an increase in tourist may cause locals to become irritated if they feel that their way of life is being threatened. E.g. Rich tourists who are accustomed to a certain way of life; their attitude towards the quality of service provided at a destination may cause the locals to feel threatened.

Fireworks Factory Essay

Jerry Yu is an American born Chinese man with an MBA who runs a small family chain of businesses in New York. He is faced with a decision to invest in the Chinese fireworks industry. Jerry must assess the attractiveness of the fireworks industry along with the risks involved. Throughout this paper we will analyze the pros and cons of entering the market of Chinese fireworks. In our opinion, Jerry Yu should not invest in the Liuyang fireworks factory. While there are many factors that could give Jerry the opportunity to be successful, the low profit margin and the high instability of the market outweigh the chances of success. The regulations throughout the fireworks industry varies from market to market. For example, China’s domestic market has deregulated since 2005, while the American market remains regulated. The high competition paired with the low selling prices due to undercutting has caused the profit margin to decrease, especially for new entries. The reason for this is that the established fireworks companies have long term contracts with suppliers, causing Jerry to sell his fireworks at a lower price. Established companies also cause a problem because of their relationships with the raw material suppliers. Due to their longstanding relationships, these companies have a right to supplies before the new entries. This results in the new entries receiving lower quality materials, leading to a worse product and less safe working environment. Even though technology is involved in the production of the fireworks, the cheaper quality materials cause a greater risk of an accident during the manual mixing of powders, which is the most dangerous step. The risk of an accident is so high that most factories are built in rural areas near a water source with separated departments in case of an explosion. Another factor that should be considered is the environmental hazards of fireworks production and use. With an increase concern for the environment and â€Å"going green†, stricter regulations have been put into place. With the new restrictions and concern to avoid pollution, the consumption of and desire for fireworks could eventually fade away. Substitutes have already entered the market that are more environmental friendly. These substitutes include popping of red balloons and laser light shows. Considering all of the risks, along with the entrance of substitutes, we advise that Jerry Yu not invest in the Chinese fireworks industry. Jerry Yu has many factors to consider involving risk  associated with the Chinese fireworks industry; however, there are many advantages in investing that he should not overlook. The Chinese fireworks industry is a highly competitive market. With over 6,000 companies, it is hard to differentiate products. The attractiveness of investing in the industry is that there is easy entry. In Liuyang, there are over 400,000 laborers working in the industry, and this makes for low cost labor and easy access to skilled labor. While the majority of workers in China are not skilled, the residents in Liuyang have gained experience with producing fireworks. Jerry has an opportunity to use this to his advantage. If he can rework the business structure of the company previously run by the village, he can set his factory apart from the average family run and operated businesses. Jerry Yu must recognize that in 2009, the current market size is $675 million, and if he plays his cards the right way, he can grab a large portion of the market share. In order to do this, his factory should have a competitive advantage. The question is, how can he go about this? We believe that he can achieve this goal by building his factory to be different from all others in the industry and specializing specifically in fireworks instead of firecrackers. Jerry Yu needs to create a niche where he, and only he, has the ability to make the highest quality of fireworks in the world. He must create a marketing strategy that has not been introduced to the current market, and he must hire the most qualified engineers to make the safest and most extraordinary combination of fireworks that exists. In doing so, Jerry has an opportunity to push the technology bubble to a place that fireworks have never been before. Creating a more unique, high quality product that will blow the competition away will give Jerry the ability to set his prices higher than other manufacturers. Jerry does not need to concentrate his sales upon the low cost average firework sales that sell in bulk, but he must sell a few high quality fireworks that give him a large margin. He needs to stay away from the price competition, and the way he will do this is by creating a niche firework that the world has never seen before. One way that Jerry can set his factory apart from other firework competitors is to embrace the new and changing technologies. Instead of looking at lasers and music as negative competition, he can make an alliance with them. Jerry can team up with a laser light show and a music show to complement the firework display. Creating a bundle package for the most  elite firework show that the world has ever seen is an answer to the niche market that Jerry should pursue. Jerry Yu should also focus on brand advertising and brand awareness, so his brand of fireworks can stand out above the other businesses in the market. He could create a marketing campaign that emphasizes that his fireworks are the best in the world, as well as the safest. A major objective for Jerry Yu should be to aim for a specific, high paying target market. The competition is high in the basic firework industry, and entering this market would result in price gouging; this would be too hard for Jerry to gain market share at this level. He will have to set his product apart from what already exists. He should guarantee that his fireworks are the safest and highest quality, which can give him the competitive advantage to target high paying customers. For example, Jerry Yu does not need to concentrate his sales to the common buyers. He should aim to get his product to a popular show, such as the Beijing Olympics, or to high paying customers in the United States and Europe where the price is not a huge concern. In ensuring his high paying customers of safety and quality, there will be very few businesses, if any, that can compete with Jerry. While the objective of Jerry Yu should be to aim at a particular market, this goal is not in the best interest of Liuyang Firecrackers and Fireworks Industry Department to go that route. In our opinion, Jerry Yu should advise Liuyang to encourage its citizens to consolidate its family owned businesses into bigger corporations. As of now, one of the only ways to differentiate products is by undercutting other manufacturers’ prices. The entire industry should focus on a way that each company can pull away from price gouging and work together to make sure the prices stay at a constant medium that will benefit all of the manufacturers. One way businesses could do this is to designate certain types of fireworks and firecrackers to be made by specific manufacturers or areas. In doing so, the designated companies could increase productivity and steer clear of price gouging. After analyzing the circumstances associated with entering the Liuyang fireworks factory, we believe Jerry Yu should not invest his time and money into the market because the risks highly outweigh the benefits. The market is too unpredictable, restricted, and saturated to guarantee a successful investment. If Jerry Yu did take on this investment opportunity, the costs he would endure to improve the company would not be  worth it in the long run. With the industry being the way it is, it would be difficult for Jerry Yu to become profitable.

Farmers Suicides in India †A Bane To Agriculture

Farmers Suicides in India – A Bane To Agriculture Free Online Research Papers Agriculture is India’s lifeline. We must work towards strengthening it.The Indian Farmers should live long and prosper. Their families shall flourish in all aspects of life.We should contribute our efforts and life experiences to bring out the best in them and improve their quality of life. In the 1990s India woke up to a spate of farmers suicides. The first state where suicides were reported was Maharashtra. Soon newspapers began to report similar occurrences from Andhra Pradesh. Suicides in general, including farmers’ suicides, are a sad and complex phenomenon. Hence, their Underlying causes need to be addressed within an equally complex societal framework. In recent years, a large number of suicides have been reported, mostly resulting from the consumption of toxic pesticides by farmers in some cotton-growing districts of central and southern India. According to some official statistics, between 2001 and the summer of 2007, more than 4,500 cases of farmer suicides were reported in the four states of Andhra Pradesh, Karnataka, Kerala, and Maharashtra (Mukherjee 2007). Other sources have reported much higher figures: in particular, the National Social Watch, a coalition of civil society organizations, reports 11,387 farmer suicides in the same period in India, almost all in those four states (The Statesman 2007), while the National Crime Records Bureau reports more than 16,000 farmer suicides every year. In most cases, male farmers committed suicide after experiencing failed crops and increased indebtedness. The largest number of reported cases was concentrated in districts of northeast Maharashtra (Vidharba District), northwest Andhra P radesh, and northern Karnataka, where cotton was increasingly planted in the 1990s in response to demand generated by the large textile industry in Mumbai (Saunders2007). Over a lakh has been accounted and one in every eight hour is taking place. These numbers may look like the statistics of clientele build up of an upcoming BPO company, but unfortunately are the statistics of farmers suicide in India, the other side of an emerging Global economic giant. Excuses like Globalization, economic transition corrections and world economic scenario etc are surreal. The problem is our urban and neo urban ruling class and their laptop economic plans, whose agenda can never grow beyond statistics and stimulations. The crisis small farmers in India face as a result of globalization and government apathy. For the past ten years farmers have been committing suicide in Vidarbha, Maharashtra, Andhra Pradesh, and Karnataka as in many other parts of India. More than 1.5 lakh farmers have committed suicide across the country in the last decade due to financial distress, as per government’s report to the Parliament of India. The main act of this tragedy started in mid 60s with the introduction of the Green Revolution. Earlier, farmers saved their own seeds and practiced organic farming. The money they invested on their farms was very little. But with Green Revolution farmers were asked to buy seeds, fertilizers and pesticides, forcing them to borrow, mostly from private money lenders at exorbitant interest rates. With every farming season their debt increased and over the course of years it led to a loan trap. The second phase of this tragic situation can be directly attributed to globalization. Under the WTO (World Trade Organization) regime, which favors wealthy industrialized countries, the Indian government has eliminated or reduced its support to farmers, while Indian agriculture is invaded by multinationals. In April 2007 an NGO named Green Earth Social Development Consulting brought out a report after doing an audit of the state and central government relief packages in Vidarbha. The reports conclusions were: Farmers demands were not taken into count while preparing the relief package. Neither were civil society organizations, local government bodies, panchayats etc consulted. The relief packages were mostly amalgamations of exiting schemes. Apart from the farmer helpline and the direct financial assistance, there was scarcely anything new being offered. Pumping extra funds into additional schemes shows that no new idea was applied to solve a situation where existing measures had obviously failed. The farmer helpline did not give any substantial help to farmers. The basis for selection of beneficiaries under the assistance scheme was not well-defined. Also, type of assistance to be given led to problems like a farmer needing a pair of bullocks getting a pump set and vice versa (or a farmer who has no access to water sources being given pump sets) Awareness regarding the package was also fairly low. Thus, suicides are supposed to be the last steps of desperation, apparently driven by growing burden of debt. Its time that we, the people call up on the power for solutions. We do not want anymore farmer suicide. By: Prof.Jasmeet Kaur MBA VNS (IT) Research Papers on Farmers Suicides in India – A Bane To AgriculturePETSTEL analysis of IndiaArguments for Physician-Assisted Suicide (PAS)Genetic EngineeringNever Been Kicked Out of a Place This NiceInfluences of Socio-Economic Status of Married MalesMarketing of Lifeboy Soap A Unilever ProductThe Relationship Between Delinquency and Drug UseThe Effects of Illegal ImmigrationAssess the importance of Nationalism 1815-1850 EuropeEffects of Television Violence on Children

Lonesome George Was the Last Pinta Island Tortoise

Lonesome George Was the Last Pinta Island Tortoise The last known member of the Pinta Island tortoise subspecies (Chelonoidis nigra abingdonii) died on June 24, 2012. Known as Lonesome George by his keepers  at the Charles Darwin Research Station on the Galpagos Island of Santa Cruz, this giant tortoise was estimated to be 100 years old. Weighing 200 pounds and measuring 5 feet in length, George was a healthy representative of his kind, but repeated attempts to breed him with biologically similar female tortoises proved unsuccessful. Scientists at the research station plan to save tissue samples and DNA from Georges body in hopes of reproducing his genetic material in the future. For now, though, Lonesome George will be preserved via taxidermy to be displayed at the Galpagos National Park. The now-extinct Pinta Island tortoise resembled  other members of the Galapagos giant tortoise species (Chelonoidis nigra), which is the largest living species of tortoise and one of the heaviest living reptiles in the world.   Characteristics of the Pinta Island Tortoise Appearance:  Like others of its subspecies, the Pinta Island tortoise has a dark brownish-gray saddleback-shaped shell with  large, bony plates on its upper portion and thick, stumpy limbs covered in scaly skin. The Pinta Island has a long neck and toothless mouth shaped much like a beak, suitable for its vegetarian diet. Size:  Individuals of this  subspecies were known to reach 400 pounds, 6 feet in length, and 5 feet in height (with necks fully extended).   Habitat:  Like other saddleback tortoises, the Pinta Island subspecies primarily inhabited arid lowlands but likely made seasonal migrations to more moist areas at higher elevations. Its primary habitat though would be that of the Ecuadorian Pinta Island from which it gets its name.   Diet:  The Pinta Island tortoises diet consisted of vegetation, including grasses, leaves, cacti, lichens, and berries. It could go for long periods without drinking water (up to 18 months) and is thought to have stored water in its bladder and pericardium. Reproduction:  Galpagos giant tortoises reach sexual maturity between 20 and 25 years of age. During the height of mating season between February and June of each year, females travel to sandy coastlines where they dig nest holes for their eggs (saddlebacks like Pinta tortoises typically dig 4 to 5 nests a year with an average of 6 eggs each). The females retain sperm from a single copulation to fertilize all of her eggs. Depending upon temperature, incubation can span anywhere from 3 to 8 months. Like other reptiles (notably crocodiles), nest temperatures determine the sex of hatchlings (warmer nests result in more females). Hatching and emergency occur between December and April. Lifespan/;  Like other subspecies of  Galpagos giant tortoises, the Pinta Island tortoise can live up to 150 years in the wild. The oldest known tortoise was Harriet, who was approximately 175 years old when she died at an Australia Zoo in 2006. Geographic Range/;  The Pinta Island tortoise was indigenous to Ecuadors Pinta Island. All subspecies of the Galpagos giant tortoise are found only in the Galpagos Archipelago. According to a study released by Cell Press entitled Lonesome George is not alone among Galapagos tortoises, there may still be a Pinta Island turtle living among a similar subspecies on the neighboring island of Isabela.   Causes of Population Decline and Extinction of Pinta Island Tortoises   During the 19th century, whalers  and fishermen killed Pinta Island tortoises for food, driving the subspecies to the brink of extinction by the mid-1900s. After exhausting the tortoise population, seasonal seafarers introduced goats to Pinta in 1959 to ensure they would have a food source upon landing. The goat population grew to more than 40,000 during the 1960s and 1970s, decimating the islands vegetation, which was the remaining tortoises food. Pinta tortoises were originally considered extinct during this time until visitors spotted Lonesome George in 1971. George was taken into captivity the following year. Following his death in 2012, the Pinta Island tortoise is now considered to be extinct (other subspecies of Galpagos tortoise are listed as Vulnerable by the IUCN). Conservation Efforts Starting in the 1970s, varied techniques were employed to eradicate Pinta Islands goat population in order to discover the most effective method for later use on larger Galpagos islands. After almost 30 years of only moderately successful extermination attempts, an intensive program of radio-collaring and aerial hunting aided by GPS and GIS technology resulted in complete eradication of goats from Pinta. Monitoring projects have since shown that Pintas native vegetation has recovered in the absence of goats, but the vegetation requires grazing to keep the ecosystem properly balanced, so the Galpagos Conservancy launched Project Pinta, a multi-phase effort to introduce tortoises from other islands to Pinta. How You Can Help Other Giant Tortoises   Donate to the Lonesome George Memorial Fund, established by the Galpagos Conservancy to fund large-scale tortoise restoration programs in Galpagos over the next 10 years. There are also a variety of  resources for  volunteering to help endangered species  available online.

15 Last Minute SAT Tips You Should Remember

15 Last Minute SAT Tips You Should Remember SAT / ACT Prep Online Guides and Tips You only have a couple days before the SAT (or maybe less than a day!), and you’re determined to ace this test! Whether you're looking for last-minute study tips, advice on how to prepare the day of the test, or test-taking strategies to maximize your scores, I've got you covered. Here are a bunch of handy last minute SAT tips that will help you stay focused and raise your scores. General Last Minute Studying Tips Ideally, you'll want to start studying for the SAT long before your test day in order to be well prepared for the exam. However, last minute studying can also be useful for learning some final pieces of information and being fully prepared.If you're studying right before the SAT, you should spend your remaining time wisely.Follow these tips to ensure that the extra effort pays off! Tip 1: Focus on Your Weak Spots It’s tempting to just â€Å"study† by taking a bunch of practice tests, but that can only help your scores so much.Now is the time to drill down into your mistakes and analyze the reasons why you made them. Make sure you understand the route to the correct answer and why your answer choice was incorrect.Even if you just do this for one section, you should start to see major score improvements. Tip 2: Be Time-Conscious You don’t want to be taken by surprise when you hear â€Å"time’s up† on the SAT, and you haven’t gotten to all the questions.Don’t take a whole practice test, but do a few questions and experiment with estimating how much time you’re spending on each.This will help you get a sense of how long 30 seconds or a minute feels so you'll know when you need to skip questions on the real test. You shouldn't be spending more than a minute on SAT Readingquestions or more than 30-45 seconds on SAT Writing questions. On the Math section, I also recommend initially spending no more than a minute on each question in both portions. You technically have more time per question on the calculator part than on the no calculator part, but it's better to be safe than sorry. If you linger too much, you won't have the chance to answer easy questions later in the section! Day of the Test Follow these tips on the morning of the SAT to ensure you start the test prepared and on the right foot. Tip 3: Sleep Strategically Go to bed early, and try to sleep at least seven hours the night before the test. Plan to wake up an hour earlier than you have to;if you just roll out of bed, you might still be sleepy when the test starts. You should be totally alert by the time you get to the test center. Tip 4: Don’t Take the Test Hungry Unless you’re one of those people who gets nauseous if you eat breakfast, you should try and eat before the test.Don’t eat too much (you don’t want to get sleepy again), but snack on something small and high in protein so your brain has something to work with, and visions of waffles don’t start dancing in your head during the test.Also,bring a couple of filling snacks that you can eat during breaks if you end up getting hungry again (nuts and granola bars are good). As for whether you should drink coffee...that depends on the person. If you're already a coffee addict, then you're probably fine with drinking a cup or two before the SAT. Don’t drink it if you’re not used to it because the caffeine could make you anxious and less focused on the test. Tip 5: Dress for Success You want to dress as comfortably as possible.Bring layers so you don’t get distracted by being too hot or too cold. You should also pack up everything you need for the test the night before to ensure that you don’t forget anything. Here's a list of what you should bring to the SAT in case you don't know: Admission Ticket Photo ID Two #2 pencils (non-mechanical) and an eraser Calculator Watch (there will be a clock, but it's easier if you can check the time on your wrist) Water and snacks Wear whatever is most comfortable for you. The testing room is a judgment-free zone. But you might want to take off the mascot head so that you have enough peripheral vision to see your answer sheet. During the Test You'll want to be on your "A" game for the entire SAT. Follow these tips to get the best test-testing experience. Tip 6: Don’t Freak Out It’s much easier said than done - sometimes the more I try to get out of my own head the less successful I am.But really try and shut out anxious thoughts that arise during the test. Do a little mini mindfulness session where you focus on your breathing and nothing else for a couple of seconds. This will lower your blood pressure and clarify your thinking. Remember, the most productive thing you can do right now is to keep on going even if some of the questions scare you.Don’t let yourself fall victim to the vicious cycle of anxiety - lost focus - less efficient test taking - can’t finish sections - MORE ANXIETY. Tip 7: Skip It If you come up against a difficult question, don’t spend a ton of time on it.Already spent a minute looking at a math or reading question and don’t know how to answer it? Skip it.Spent more than 30 seconds looking at a writing question with no success? Skip it. You can circle the questions you skip and come back to them at the end if you have extra time.If you let yourself get bogged down, you might not make it to future easier questions that could earn you more points. Tip 8: Always Guess There's no penalty for wrong answers, so make sure to put something down for every question. Even if it's a completely random guess, there's a chance you'll get it right and earn the point. Tip 9: Take the Breaks Even if you don’t feel like it, take advantage of breaks.They can help reduce your stress and remind you that there's a whole new world that exists outside the testing room.Eat a snack, use the bathroom - you’ll probably feel much more refreshed and prepared to take on the rest of the test. Tip 10: Check Your Answers! Have a few minutes at the end of a section?I know you’re tired, but go back and check your answers.Dumb mistakes are frustrating, and usually they can be corrected if you just look over the questions again. You can also use this time to make sure you filled out the answer sheet correctly and didn’t accidentally skip a question and bubble in the wrong answers. Tip : Use Evidence in Your Essay If you're planning on taking the (now optional) essay portion of the new SAT, you'll have to read a passage and analyze the author's argument. Make sure that you use direct evidence from the passage to back up your points and show the validity of your analysis. As you're reading the passage, underline any sentences or phrases that you think you might use in your essay to explain how the author builds an argument. Tip 12: Use Everything the SAT Gives You, and Take Shortcuts This applies to all sections of the SAT. If youthink you couldn’t possibly figure out the answer to a question, make sure you exhaust all resources at your disposal before guessing (although as I said, you can skip it on your first pass through the section!). Remember that this isn’t like a normal test. No one cares if you show your work or use the â€Å"right† method to solve a problem, so take shortcuts to solutions if you can find them. Here are some relevant things to keep in mind about each section: Reading On reading, don’t be intimidated by an unknown word. Especially on the new version of the SAT, you can almost alwaysuse context cluesto approximate its definition. Save time by skimming the passages in the reading section when you first get to them. If you need to you can read certain sections more closely later to answer specific questions. Take reading passages at face value.If the answer isn’t DIRECTLY supported by what you read in the passage, don’t choose it. Writing Watch out for the â€Å"no change† answers. If you notice you’re getting a lot of them (more than a quarter of your answers to questions that have "no change" as an option), check those questions again to make sure you didn’t miss something. Study thegrammar rules that are on the SAT, follow them, and don’t overthink it. Math Sometimes math problems will give you a diagram of a shape, and you're supposed to find an area, angle measurement, or other dimension. Usually, the most logical answer based on what you see is correct. For example, if you're trying to find the measurement of a tiny-looking acute angle, you can rule out 80 degrees as an answer. On the calculator portion of the Math section, use the computing power of your calculator to its full advantage. If you come across questions about graphs of equations, use the graphing function. At the same time, don't overuse your calculator to the point where it's costing you more time. Be smart about when you need it and when it's faster to just do things the old-fashioned way. And if you haven’t already, reviewthis list of formulas you should know for the SAT. If you start to do something crazy and complicated for a math problem, you’re probably going down the wrong path! The SAT tests simple concepts that are sometimes presented in weird formats. Above all, remember that multiple choice is a gift; the answer is right in front of you even if you don’t see it right away. Oh boy, I hope it's Multiple Choiceâ„ ¢! After the Test Even after you've finished the SAT there are still some important tips to keep in mind. Tip 13: Be Aware: You Can Cancel Your Scores If you're concerned about your scores because you know something went horribly wrong on the test, you are allowed to cancel them. You must submit your written request for cancelation to the College Board by midnight on the Wednesday after the test. For advice on whether you should cancel your scores and how to go about doing it, read this article. Tip 14: Taking the Test Again? Consider the Question-and-Answer Service or Student Answer Service If you know you're going to take the SAT again, you should think about ordering one of the services the College Board offers for you to review your scores in more detail. These can be very useful studying tools because they will show you your weak spots in a real test environment. For more information on these services, read this article. Tip 15: Don't Get too Stressed It's important to give yourself time to decompress and relax after the test! Try not to stress out too much about what may have gone wrong. It’s out of your hands now, and your time and energy are much better spent doing other things that you enjoy for the rest of the weekend. What's Next? Are you trying to decide whether to retake the SAT? This guide will help you make a decision. Then you can start planning when you'll register for the test again. If you want to get a head start on studying for your next test date, check out these study plans for sophomores and juniors, rising seniors, and our complete plan for all students. You should also figure out your target score so you can plan accordingly. Also, check out our guides for how to get an 800 on each section of the SAT to get more specific tips for raising your scores! Want to improve your SAT score by 160 points? Check out our best-in-class online SAT prep classes. We guarantee your money back if you don't improve your SAT score by 160 points or more. Our classes are entirely online, and they're taught by SAT experts. If you liked this article, you'll love our classes. Along with expert-led classes, you'll get personalized homework with thousands of practice problems organized by individual skills so you learn most effectively. We'll also give you a step-by-step, custom program to follow so you'll never be confused about what to study next. Try it risk-free today:

The Evolution of wall painting Essay Example | Topics and Well Written Essays - 500 words

The Evolution of wall painting - Essay Example The essay "The Evolution of wall painting" explores the wall painting and the stages of its evolution. In the religious setup, the styles of Frescoes and Mosaics are widely used, narrating the life of the Virgin Mary and Jesus. From them, one can draw a conclusion that, though wall painting changed, it remained the same in different setups. This paper seeks to explore the evolution of wall painting beginning in Paleolithic period to Early Renaissance.During the Paleolithic period, wall painting decoration was either decorated objects or figurines. From about 31, 000 to 12, 000 B.C, there were two main categories of painting, which were either decorated objects or portable pieces. Portable pieces were small figurines, while decorated objects were carved out of stone, clay, and also cave art. Paleolithic art majored itself in different subjects such as animal carvings, hunting scenes, and animals. It was an attempt to gain control over the environment through critical thinking. One can imply that painting was a powerful tool of revealing different ideas and concepts of the society. Wall painting was carried out in different colors, but mostly golden brown was used to reveal the beautiful nature of the painting. The following is an example of a wall painting of the Paleolithic period that depicts animals. The walls were covered with different paintings that revealed different subjects. In most cases, animals were the subject shown through shades of brown, red, black, and yellow.

Letter about a product Essay Example | Topics and Well Written Essays - 500 words

Letter about a product - Essay Example I am looking forward to hearing from Emerson Process Management because I feel that I am a strong candidate for the vacant position. I shall keep you posted about the progress of my application with the aforementioned company. Greetings! I am contacting you today in relation to the job opening of Materials Analyst at your good company. It is by sheer luck that I am currently available to fill the position should you feel that I qualify to do so. I have almost 12 years on the job experience as a Materials Analyst having had the opportunity to work for ABC Processes Incorporated in the same position up until the time of my departure from the company this past January. I have traveled extensively across the United States as a representative for ABC Processes Incorporated and have created a personal network of business connections in the process that can benefit Emerson Process Management whenever necessary. I believe that my attached resume will prove that I am one of the strongest candidates for the open position. I am available to discuss my application and answer any questions you might have about my work experience at your convenience. I am looking forward to hearing from you about an interview date are your most convenient

Participating in team sports helps to develop good character in Essay

Participating in team sports helps to develop good character in chidren - Essay Example Though the results from these studies are somehow conflicted, there is a solid argument that sports are influential in developing good character in children. Is character intrinsic in human beings? To comprehend this, one must understand the definition of character. The term â€Å"character† is employed to refer to an encompassment of qualities that make an individual distinguishable. These qualities are usually complex, which psychological and ethical influences shape an individual character. These definitions make it evident that character is not intrinsic. This is because of its psychological and ethical inclinations. These two factors are external and are influenced by an individual’s interaction with life. Good character may be defined as conducting oneself in a manner that is socially accepted. Therefore, for a child to have good character, it is imperative that they interact with the society in order to know what is accepted to be good and vice versa. Therefore, interactions such as sports may have a significant influence on character development in children that are positively viewed in the community. Children participation in team sports clearly has a consequence in the development of character in children. This is because sports make available an opportunity for children to learn qualities that entail good character. Some of these qualities include commitment, discipline, and teamwork among other qualities that are regarded as good character. Children, through sports, also understand better human relationships and how best to relate in society. The characters that are learned through sports influence the child’s life decisions in his or her lifetime (Dunlap, 2004). Character development in children is evident in sports through the development of principles. Principles depicted to be of good character include honesty, compassion, integrity, self-control, courage, hard work, etc.. These principles are learned in sports

The Use of Sociological Research in Public Debate Issues of Social Essay

The Use of Sociological Research in Public Debate Issues of Social Deviance - Essay Example On the other hand are the post modernists, who believed that these events are part of sociological change brought about by different factors, and thus, should not be remorsed but embraced. The two principles are governed by sets of reasons, but what drove them to stand is the information brought about sociological research. Sociological research on teenage pregnancy and co-habitation aims to transmit understanding to the people, in such a way that it would reconcile the traditionalist thought and modernist thought; however, it does not deny the possibility of widening the gap between the two principles. Sociology Sociology is the scientific study of the origins and development of organizations and the relationship of each person to their society. There is known to be an irrevocable relationship of an individual’s experiences to the whereabouts of his society; a person affects society as much as society affects the person (Newman, 2010, p. xxii). This seems to be a chicken-and- egg question, but truth remains that not one sociologist can pin point which affects whom and vice versa because society and people are two nondetachable elements. Sociological research’s use is to examine the problems of the society, the reasons of such problems, and if those problems are still considered problems in the modern world, especially that several factors are present influencing social issues. Plummer (2010, p. 3) sees Sociology as a â€Å"critique and wonderer† who continually thinks and appreciate the â€Å"complex patterns of social life.† Complex, in a sense that people’s social thoughts are evolutionary, and sometimes, more negative perspectives than the positive ones show, described by Plummer (2010, p. 4) as a â€Å"march of humanity’s inhumanity.† As varied as the cultures of people, sociological research respects cultural norms. The studies are helpful in beginning to end bigotry, and begin tolerance in understanding oth er cultures and stresses the importance of eliminating bias, although at times it may be unstoppable. Issues such as teenage pregnancy and cohabitation are two most common social deviants, where both are favorite topics of formal and informal arguments. Teenage Pregnancy and Early Motherhood as a Public Issue There are a number of factors which may contribute to the widespread of early sexual experience among teenagers. An alarming 41,329 girls under age 18 became pregnant in 2008 (Rogers, 2010). This statistical record is already around 3% lower than what the nation made in 2007 but the decrease is not really a significant number to rejoice about because it represents only a small percentage of the total pregnant teens’ population. Adding to the reckless potential of the media is the teenagers’ attitude itself towards sexual activities. In Liscio’s (2011) report, the issue holds a different case, mentioning about the brighter side of teenage pregnancy. Accordin g to the study, teenagers are more likely to â€Å"re-engage themselves at school once the baby is born.† This is probably due to a human’s parental instinct, that is one should have a child of his own, it is obligatory to give him or her brighter future. As education becomes a key of having better job opportunities, teenage parents do their best in academic performance. However, this does not make the issue at least acceptable because it is still an ongoing debate whether teenage pregnancy should be accepted as a part of change or should remain as a social taboo subject to restriction of discussion and adaption. Teenage mothers are forced to turn from single life’s luxury and face the responsibilities of motherhood

The Selection Process Research Paper Example | Topics and Well Written Essays - 1000 words

The Selection Process - Research Paper Example retained, the organization will not improve at its best and will suffer at its worst (Snell, Morris & Bohlander, 2015).  Human resource managers and nurse managers play a critical role in the selection process of a health care organization. The expectation of the human resource is to see the selection process has been done in a fair and transparent manner in accordance with the missions and visions of the organization. The nurse manager expects to promote a positive image for healthcare organization by selecting the right people to the right positions (Van De Voorde, Paauwe & Van Veldhoven, 2012). This paper discusses the selection process in Mayo clinic healthcare organization. Mayo clinic is a non-profit organization located in Rochester, Minnesota. The clinic is very large and it is renowned throughout U. S and internationally (Smith, Saunders, Stuckhardt & McGinnis, 2013). In regard to this, the organization offers a lot of medical job opportunities to both U.S citizens and non-citizens. Recently, there is an open job position for a nurse practitioner. Since the organization is guided by its set missions and vision, the candidate who will qualify for the job must undergo the selection process. This selection process will involve nine steps that include; Preparing a new position or reviewing an existing position that might have changed or preparing a Job Description Questionnaire (JDQ). This step is significant as it lays the base for the following steps. In these steps, the human resource will be responsible to complete some of the steps. For example, the human personnel will be the one to understand the employment laws to guide the nurse manager about the hiring and selection process. He or she will be the one to announce the vacant position, prepare the interview questions and scoring criteria. Again, the person will be responsible for screening the applications, making the selection, and performing the reference checks (Swayne, Duncan& Ginter, 2012). On

Peer response Article Example | Topics and Well Written Essays - 250 words - 7

Peer response - Article Example In terms of concerns regarding sampling, the plan to obtain a representative sample through securing a list of students in remedial classes is deemed to be an appropriate mode. Soliciting these students’ approval to participate in the study is another issue that needs a good technique. Your suggestion to send email message to these students is an alternative. However, one suggests that you could directly endorse request letters to these students while in their traditional class settings. Of course, you have to request approval from the instructors, as well as from the academic authorities prior to solicitation of approval for participation. Thus, through a quick survey-questionnaire, these same students could respond immediately in the same traditional classroom setting to collect their responses. I believe this suggestion would also eliminate sampling biases since the survey would be conducted to all students taking remedial classes in their traditional classroom

The Selection Process Research Paper Example | Topics and Well Written Essays - 1000 words

The Selection Process - Research Paper Example retained, the organization will not improve at its best and will suffer at its worst (Snell, Morris & Bohlander, 2015).  Human resource managers and nurse managers play a critical role in the selection process of a health care organization. The expectation of the human resource is to see the selection process has been done in a fair and transparent manner in accordance with the missions and visions of the organization. The nurse manager expects to promote a positive image for healthcare organization by selecting the right people to the right positions (Van De Voorde, Paauwe & Van Veldhoven, 2012). This paper discusses the selection process in Mayo clinic healthcare organization. Mayo clinic is a non-profit organization located in Rochester, Minnesota. The clinic is very large and it is renowned throughout U. S and internationally (Smith, Saunders, Stuckhardt & McGinnis, 2013). In regard to this, the organization offers a lot of medical job opportunities to both U.S citizens and non-citizens. Recently, there is an open job position for a nurse practitioner. Since the organization is guided by its set missions and vision, the candidate who will qualify for the job must undergo the selection process. This selection process will involve nine steps that include; Preparing a new position or reviewing an existing position that might have changed or preparing a Job Description Questionnaire (JDQ). This step is significant as it lays the base for the following steps. In these steps, the human resource will be responsible to complete some of the steps. For example, the human personnel will be the one to understand the employment laws to guide the nurse manager about the hiring and selection process. He or she will be the one to announce the vacant position, prepare the interview questions and scoring criteria. Again, the person will be responsible for screening the applications, making the selection, and performing the reference checks (Swayne, Duncan& Ginter, 2012). On

Nature, representation and value of sexuality in The Buddha of Essay

Nature, representation and value of sexuality in The Buddha of Suburbia by Hanif Kureishi and The Gangster of Love by Jessica Hagedorn - Essay Example Charlie had the additional advantage of the able and valued advice of his ex-guru dad! How simple was the suburban life. Hanif provides an apt description: "We were proud of never learning anything except the names of footballers, the personnel of rock groups and the lyrics to I Am the Walrus.†(p.178) Karim Amir gives the frank self-introduction, befitting the teenager of the 1970s in the suburban London, as â€Å"a funny kind of Englishman, a new breed as it was, having emerged from two old histories† (Kureishi, p. 3). Hanif weaves several other stories, around the life of Karim. He creates situations through which Karim is obliged to react the way he reacts. He has no ideal on which he can build his life in a disciplined manner. He gets wrong idols and Karim makes use of them, as a directionless youngster would! Count his misfortunes/fortunes one by one. His dysfunctional family, his best friend with a rebellious daughter, her peculiar Indian-based friend Changez, Charlie who is the object affection, several theatre actors with whom he has opportunistic relations—Karim’s sex and sarcasm goes hand in hand. Hanif describes the problems of adolescent Karim Amir growing into manhood. How he learns about himself and the world around him and discovers the operati ve rules of family, work, institutions, society, and culture. Karim Amir’s own schooling proves to be an adventure, quite contrary to the gloomy atmosphere at home. He has affairs with Eleanor, Jamila etc. that provide him much excitement. His companions also teach him sex by example, About Charlie Karim says, â€Å"No, Charlie was the cruelest and most lethal type of seducer. He extorted not only sex, but love and loyalty, kindness and encouragement, before moving on. I too would gladly have exercised these master-skills, but †¦Ã¢â‚¬  (p.119) Once Karim’s father receives the official sex-license, the possibilities of business in the line are immense! Hanif describes it in style: â€Å"Was

The Psychological Effects of Change Management

The Psychological Effects of Change Management An organization is a system of interacting subsystems and components set within wider systems and environments which provide inputs to the system and which receive its outputs (Senior, 2002, p.5). That is why each organization affects the system but is being modified by the latter as well. According to Armstrong (2009, p.404), as there is no such thing as ideal organization the change is vital. The author argues that by facing each problem, the organisation should be modified in order to achieve the best fit between the structure and the circumstances (2009, p. 405). On the other hand, an organization has different components such as employees which are the essential assets for a company, highly likely they will be affected from the change management of the organization in different ways. There is no doubt that the most important impact is the psychological one for the employees which is considered as resistance to the new management system. These effects should be managed carefully in order to facilitate the change process. Contrary to those who believe that change can only be successful through coercive measures, this paper argues that change must be implemented through a positive approach which consists of a dialogue process with employees. The communication and the presentation of the change management plan will allow employees to express their thoughts and feelings about it. Because their reaction is taken into account, they will feel part of the change process, and they will be more likely to adapt to a given change. This, at the end, will ease the implementation of change, and will help the company to finalize this process in a more peaceful and successful way. Firstly, the concept of change management concept will be explained briefly. Secondly, the concept of resistance and the psychological effects on the employees such as shock of the new, inconvenience, fear of failure will be discussed, and finally, the mitigation methods which depend on the choice of change management programme will be enum erated such as communication, presentation of the change management plan, and bargaining which will be discussed with their effects. THE CONCEPT OF CHANGE MANAGEMENT The change management is the way of dealing with a possible change process since that every company should be ready for a potential modification in the system in order not to be effected by it in a negative way. The concept is defined by Armstrong such as the process of achieving the smooth implementation of change by planning and introducing it systematically, taking into account the likelihood of it being resisted (2009, p.424). Although the change is the only thing that stays constant in the organization (Armstrong, 2009, p.424), and that is the reason why the change management has a vital place in the organizational life. Change starts with a need of modification in the system and happens during a process. Even though nothing disturbs the organizational life, change will happen in a range of time (Senior, 2002). The reason why the change emerges can be internal or external. The former consists of a revision of the administration, redesign of group jobs, external factors can be ei ther social-cultural or political (Senior, 2002, p.5). There exist three types of change: strategic change which is a long term modification, operational change which is related to a change of a part of an organisation and transformational change which affects dramatically the structure, the process and behaviours of the organization (Armstrong, 2009, p.425). In either way a change management programme is highly required to companies. There is a variety of change programmes, and everyone has its own approach, but five characteristics are common between these according to Binney and Williams : vision, telling people what that vision is, top management determination, planning and programming and adopting the best practice (2005. p.296). The management process aims success by decreasing the resistance against the change. The PSYCHOLOGICAL IMPACTS OF THE CHANGE MANAGEMENT The change management has psychological effects on employees because of the fact that every modification creates a resistance to the organization. As the former will create a new system for them, it can be said that every change management programme is the change itself. As psychological impacts, shock of the new (Armstrong, 2009, p. 431) can be cited, it means that employees will go through a process that they do not know, and they are afraid of it since it is unknown: the new situation will be distinct from the routine. There is also inconvenience (Armstrong, 2009, p.431) because they may think that their life may be more difficult than the previous one. Moreover, the change causes economic fears and uncertainty of the new situation and the latter symbolises a threat to interpersonal relationships that they build during their former organizational life. The new system will probably bring new rules, and they will need to integrate themselves to the new procedures: as to Steers and Black, they may doubt about their competences and they may have a fear of failure (1994, p. 669). Furthermore, it is also the fact that group norms and role prescriptions can be changed and their status may not be the same as the former. As it has been enumerated before, the employees will face a different aspect of their own organization, their habit and their group norms will change and there will be multiple effects on their psychology. That is the reason why employees will show some kind of a reaction called individual resistance (Steers, Black, 1994, p. 668) to the implication of the change management. The resistance can even cause the failure of the im plementation since employees are the most important assets of the organization. The psychological impact has been covered of five stages by Carnall (1990), which can be helpful to understand the resistances change. These five steps are general ones which employees pass through during the process of change. The first stage is denial (1999, p.211) where the employee does not admit that he needs a change in the organization and tries not to accept any changes with a disbelieve to his employers. Carnall argues that it is a warning period and there will be no decrease of performance. The second stage is the defence(1999, p.212) where the employee gets the new position or the new environment but does not want to do it and find excuses related to the new situation. The third one is discarding (1999, p. 212) when employee starts to let go the past, and starts to getting used to the new procedure. This is where employee accepts that the change was inevitable (1999, p.213). Stage four is adaptation (1999, p. 213) where the integration of the employee is realized and every thing works according to the plan. The last one is the internalization where the new change management plan has been became a normal one (1999, p.214): it is the phase where the normalization of the behaviour occurred. The MITIGATION of THE PSYCOLOGICAL IMPACTS The psychological impact should be mitigated in order to realize the change management aimed. Human element is the prime benchmark at this point, it means that every effort must be made according to the interests of those who have been affected by change (Senior, 2002). Mitigation will help to make the employees accept the change management more easily and adapt them to the new sturucture that they are willing to face. It should be underlined that the mitigation effect depend on the change management nature that has been chosen by the administration. Overcoming the psychological effects can be done in multiple ways, the best is to present the change management programme to the employees and try to get them into the project in order to reach a better level of integration. The communication is essential at this point (Armstrong, 2009), it does not mean that the employee will have influence on the change, but at least they will be able to predict their future, which will bring the decrease of the fear that they feel. It is not necessarily an active participation of employees, but an explanation of the reasons why the company choose to make a modification on the current model of management, and its plan in order not to make frighten employees. Every affects that will be faced depend on the introducing method; it may make people a part of the plan and will push them to collaborate with the company. After communication process, the company should also identify the possible fears and their reasons, and after, the administration should find ways to resolve the problems which may occur during the process (Armstrong, 2009). This kind of an attitude will not only help the integration of the employees to the new system but also will provide more credit to current the administration. On the other hand this communication phase can be done as participation to the decision making. The administration can listen to the employees carefully and take them idea as well for understanding in a better way their point about the change (Beech, Kenna, 2008, p. 95). In that case alienation of employees to the change will be less. The company could choose a step forward of communication: bargaining. In that case the employee is having a role in the process. Thurlys model is a well example, this plan has five steps as directive, bargaining, heart and minds, analytical approach and action based. In this case, the change management is imposed to the employees by the management power at first, but then the process is negotiated between the employee and the employer which will help the administration to understand the possible psychological effects of the change, and modify the plan according to it. A brain storming is being done and the management power will find the best way to adapt the new system. In that model the employee is not only a part of the plan but also is facing the administration which will give the feeling of importance to the employee. Moreover, Beech and Kenna share the same idea, according to them when the administration choose a bargaining method (2008, p.95) the company can attract more people to collaborate in an easy way and employees who had been helped the administration can have a better position in the change management process. Furthermore, training and skill development programmes (Beech, Kenna, 2008) can be used in order to decrease the psychological impacts as fear of failure or inconvenience. On the other hand, the physiological effects can be managed by coercion (direct threat), manipulation, withholding negative data (Beech, Kenna, 2008, p. 95). There is no doubt that the administration will show it force on the employees by these methods but is should be underlined that the fear will be more in long term, and additionally the employees will lose their thrust to the administration. Beer et Al argue that people can adopt to a new organizational system and the change should be done in a sharply way but showing the overcome is always a better way, since the behaviour and conscience are related to each other (Armstrong, 2009, p. 428), and more the employee will see the outcome, the more he will adapt itself to the new situation. CONCLUSION As a conclusion, change for every company is a must since it is interrelated to the system and because of the inputs and outputs, change becomes inevitable. Every organization needs to have a change management plan for being prepared to a new organizational system. There are multiple change management programmes; their common point is their aim which is to decrease the effects of change. Additionally, to every plan there will be a resistance; it is result of fear, prejudice, anxiety and ignorance (Calmon, Paton, 1992, p. 9) the change management plan has psychological impacts on employees such as shock, inconvenience, fear of failure. They live it in five stages as denial, defence, discarding, adaptation, internalization according to Carnall. The psychological effects can be mitigated by communication, participation of the employees to the management plan and bargaining. On the other hand coercion can be a way as well, but the best way is to handle the process by a positive way becau se of the fact that the employee is the most important asset of the company moreover the programme will be more efficient, and easy to adapt.

The Design of Taipei 101 Essay -- Structural Design

Stiffness and comfort (steel outrigger trusses) The 101 story building, 500 meters high Taipei 101 is located in Taipei, Taiwan. Taipei 101 is the pride and identity of the people of Taiwan. The building represents â€Å"concept of striving for beyond perfection† (Taipei 101 anon 2005) as it outsmarts nature with its technological features. 101 building achieved a remarkable world record for the highest building in 2004 with 101 floors hence the name Taipei 101. Designing and building the 101 building was very challenging and rewarding, as it is located in one of the most hostile places in the world. The tall building is located in Taiwan, which is constantly under attack by Mother Nature, earthquake potential and typhoon winds are just common problem which the architect, C. Y. Lee & Partners, and the structural engineers Thornton Tomasetti Inc needed to solve. The engineers of the Taipei 101 made the impossible possible (Shieh et al n.d). The initial plan was to make three building with 60 storeys building in centre, but t he 60 building soon turned into 101 storey single tower building to meet investor’s demand. In order to be the most unique skyscraper in the world Taipei 101 building represents its culture (Taipei 101 Binder, 2008). In this part of the essay we are going to investigate about how is stiffness and comfort maintained in Taipei 101, we’ll be looking in depth some of the features of Taipei 101 that work together to provide stiffness and comfort. Firstly we will be looking at the stiffness and then move on to comfort features. How is Stiffness and comfort maintained by Taipei 101? To provide comfort the 101 building has to deal against the nature. Taipei 101 is located in a hazard prone environment. Typhoon and ... ...tlUvYTVMMmicsorE9tDlv1VgdZWCJDAKPfx3AOTuaIEUkm4piLesN_8NVrM131TbT8wyyRQ_0MIcIx7yVN5ho3D9NbHoZjiAx477&sig=AHIEtbQNaZZ1eKBA82LxMn_p6RZZMKxmvA&pli=1 (accessed 3.4.11) †¢ Anon. what are steel moment frames? (N.d). [online]. Available from: http://www.propertyrisk.com/refcentr/steel-side.htm (accessed 03.04.11) †¢ Brooks. C., Huff .I. The effect of high altitude or relative humidity. (2006). [online] available from: http://www.physics.umt.edu/borealis/RH%20Lab%20Report_06.pdf. (Accessed: 03.04.11). †¢ Anon, Taipei 101 expected to receive LEED platinum certification( 2010).[online]. Available from: http://www.taipei-101.com.tw/NEWSV/en/news_in.aspx?News_Sn=24 (accessed 03.04.11). †¢ Mizuguchi.h., nakagwa.t. and fujita.y. breaking the 1000mom barrier. (2005). [online]. Available from: http://www.elevator-world.com/magazine/PDF/sept05/sept05.pdf (accessed 03.04.11)